Sunday, May 20th, 2018


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Young Breast Cancer Patients Aged <40 Years and Tumor DNA Ploidy Progression
Authors:  Roland B. Sennerstam, M.D., Ph.D., and Jan-Olov Strömberg, Tekn.D., Ph.D.
  Objective: To study tumor progression in a simulation model following tetraploidization (TPZ) and the establishment of aneuploid tumors in a population of young women (aged <40 years) with breast cancer.
Study Design:
A sample of 284 women aged <40 years, retrieved from 5,875 randomized breast cancer patients treated from 1991–2000, were studied. The tumors were analyzed for chromosomal instability and proliferative activity called the stem-line scatter index (SSI). The dynamic interactive relationship between diploid, tetraploid, and aneuploid tumors was followed during increasing age and related to SSI values and tumor size.
TPZ occurred early in tumor progression in the lower ages and was followed by hypotetraploid and further down to hypertriploid tumors, in the end reaching hypotriploid tumors for women aged >34 years. During tumor progression we observed a reduced frequency of diploid tumors from 71.7% to 14.3% (p<0.00001), and triploid tumors increased from 13.2% (6≤SSI<15 relative units) to 40.2% (20≤SSI<60 relative units) (p<0.0001).
During carcinogenesis aneuploid tumors appeared mainly from genomically destabilized tetraploid tumors, subsequently reaching the aggressive aneuploid tumors mainly in the hypertriploid region. These results increase our understanding of the importance of TPZ during carcinogenesis of breast cancer.
Keywords:  aneuploid tumors, chromosomal instability, diploid, DNA ploidy, stem-line scatter index, tetraploid, tetraploidy, tumor progression
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