Wednesday, September 19th, 2018


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Expression of Cyclophilin A in the Placental Tissue of Pregnant Women with Gestational Diabetes Mellitus
Authors:  Akin Usta, M.D., Gulay Turan, M.D., Eren Altun, M.D., Ceyda Sancakli Usta, M.D., and Ertan Adali, M.D.
  Objective: To evaluate placental cyclophilin A (CyPA) expression and assess its association with maternal/fetal health outcomes in pregnant women with gestational diabetes mellitus (GDM).
Study Design:
A total of 43 pregnant women (23 GDM and 20 non-GDM) underwent a 50-g glucose challenge test (GCT) at 24–28 weeks’ gestation. A GCT cutoff of <140 mg/dL was selected. Women with an elevated GCT underwent prompt diagnostic testing via a 3-hour glucose tolerance test. Immunohistochemistry for CyPA was performed on formalin-fixed and paraffin embedded sections. Finally, the relationship between placenta CyPA reactivity and the clinical findings of GDM was evaluated.
The expression of placental CyPA was significantly different between pregnant women with GDM and non-GDM subjects. There was an increased expression of CyPA in trophoblasts, capillary endothelium, and decidua of GDM pregnancies as compared with those of non-GDM subjects (p=0.0007, 0.0012, and 0.0019, respectively). CyPA expression in the capillary endothelium was correlated with the presence of maternal/fetal complications and placental changes as- sociated with GDM. Additionally, CyPA expression in the trophoblasts was strongly correlated with placental changes.
The discovered differences indicate a possible relationship between GDM and the immunohistochemical expression of CyPA in placental tissue.
Keywords:  cyclophilin A; cyclophilins; cyclosporins; gestational diabetes mellitus; immunohistochemistry; oxidative stress; peptidyl-prolyl cis-trans isomerase A; peptidylprolyl isomerase; placental histology
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