Tuesday, December 11th, 2018


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Myocardial Protective Effects of Bivalirudin on the Improvement of Coronary Microcirculation Obstruction
Authors:  Yu Ding, M.D., Bo Li, M.D., Feng Tian, M.D., and Yundai Chen, M.D.
  Objective: To investigate the effects of bivalirudin on the disorders of coronary microcirculation as compared with heparin sodium, and to observe the function of bivalirudin responsive gene HIF-1α in myocardial cells.
Study Design:
Detection of activated clotting time (ACT) was employed in a rat model. HIF-1α mRNA and protein levels in myocardial cells were determined by qRT-PCR and Western blotting. MTT assay was employed to monitor the proliferation of myocardial cells. SPSS version 13.0 was used for statistical analyses.
Bivalirudin decreased the incidence of myocardial injury in patients and prolonged ACT in rats. It reduced coronary microcirculation obstruction. Bivalirudin induced HIF-1α in myocardial cells, and HIF-1α enhanced the proliferation of myocardial cells.
Appropriate manipulation of bivalirudin may be a better treatment for the disorders of coronary microcirculation.
Keywords:  activated clotting time; activated coagulation time, whole blood; bivalirudin; blood clotting; blood coagulation; cell proliferation; hypoxia-inducible factor-proline dioxygenases; HIF-1α; whole blood coagulation time
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