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Title:
Myocardial Protective Effects of Bivalirudin on the Improvement of Coronary Microcirculation Obstruction
Authors:  Yu Ding, M.D., Bo Li, M.D., Feng Tian, M.D., and Yundai Chen, M.D.
  Objective: To investigate the effects of bivalirudin on the disorders of coronary microcirculation as compared with heparin sodium, and to observe the function of bivalirudin responsive gene HIF-1α in myocardial cells.
Study Design:
Detection of activated clotting time (ACT) was employed in a rat model. HIF-1α mRNA and protein levels in myocardial cells were determined by qRT-PCR and Western blotting. MTT assay was employed to monitor the proliferation of myocardial cells. SPSS version 13.0 was used for statistical analyses.
Results:
Bivalirudin decreased the incidence of myocardial injury in patients and prolonged ACT in rats. It reduced coronary microcirculation obstruction. Bivalirudin induced HIF-1α in myocardial cells, and HIF-1α enhanced the proliferation of myocardial cells.
Conclusion:
Appropriate manipulation of bivalirudin may be a better treatment for the disorders of coronary microcirculation.
Keywords:  activated clotting time; activated coagulation time, whole blood; bivalirudin; blood clotting; blood coagulation; cell proliferation; hypoxia-inducible factor-proline dioxygenases; HIF-1α; whole blood coagulation time
   
   
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