Friday, March 22nd, 2019


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Papillary Carcinoma in Struma Ovarii: A Case Report
Authors:  Nataniele Piol, M.D., Bruno Spina, M.D., Massimo Giusti, M.D., Simone Ferrero, M.D., Ph.D., Carlo Toncini, M.D., and Valerio Gaetano Vellone, M.D., Ph.D.
  BACKGROUND: Thyroid-type carcinoma in struma ovarii (SO) is a very rare neoplasia which can sometimes be difficult to diagnose and treat because of the relatively poor knowledge of the disease. CASE: A 52-year-old woman with a right ovarian neoformation presented with abdominopelvic pain. A bilateral salpingo-oophorectomy was performed, and histopathological examination revealed a right ovarian teratoma in which thyroid tissue harbored a nonencapsulated follicular variant of papillary carcinoma. Total thyroidectomy ruled out metastasis from a primary thyroid tumor, and histopathological examination revealed no evidence of thyroid malignancy. Radioactive iodine therapy was performed 4 months after thyroidectomy, and the patient showed no evidence of recurrent or persistent disease after 14 months of follow-up.
Papillary thyroid-type carcinoma is reported as the most common thyroid-type carcinoma in SO and yet is a very rare disease, with only 18 cases reported in the English literature in the last 9 years. No consensus has been reached among pathologists in diagnostic criteria nor among clinicians in treatment strategy.
As thyroid-type carcinoma in SO is a rare disease, much effort is needed in developing adequate diagnostic criteria and treatment modalities.
Keywords:  carcinoma; ovarian cancer; ovarian diseases; ovarian teratoma; ovary; rare diseases; struma ovarii; thyroid cancer, papillary; thyroid neoplasms
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