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Title:
Study on Drug Resistance Mediated by Expression of HER-2 and LRP in Tumor Tissues of Patients with Gastric Cancer and Expression Correlation Between HER-2 and LRP
Authors:  Pengzhe Zhou, M.D., Honghai Yu, M.D., Gang Zhang, M.D., Jinzhuo Zhang, M.D., and Yingxia Hao, M.D.
  Objective: To observe expression of human epidermal growth factor receptor 2 (HER-2) and lung resistance protein (LRP) in tumor tissues of patients with gastric cancer and to explore the relationship between HER-2–mediated gastric cancer resistance and LRP expression.
Study Design:
Immunohistochemical method was applied to test HER-2 and LRP expression in 65 specimens of gastric cancer and 32 non–gastric cancer patients. Western blot was used to examine the phosphorylation state of HER-2 in non–gastric cancer patients and in gastric cancer patients with or without lymphatic metastasis.
Results:
HER-2 and LRP expression of patients with gastric cancer had no obvious correlation with patient age, gender, tissue differentiation degree, and infiltration depth. The research results showed that HER-2 and LRP expression in gastric cancer tissues presented positive correlation (r=0.335, p<0.05). Phosphorylation of HER-2 was highest in patients with gastric cancer and lymphatic metastasis and higher in patients with gastric cancer only, as compared to that in non–gastric cancer patients.
Conclusion:
LRP may be one of the resistance proteins causing primary resistance of gastric cancer. Activation of HER-2 may mediate gastric cancer resistance through influencing LRP expression.
Keywords:  drug resistance, gastric cancer, HER-2, human epidermal growth factor receptor 2, immunohistochemical, LRP, lung resistance protein
   
   
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