Friday, March 22nd, 2019

 

Next
A full text version of this article is available.
To access article obtain online access here or login
 
Title:
Metastasis of Prostatic Adenocarcinoma in a Lymph Node Affected by Hodgkin Lymphoma: A Case Report
Authors:  Nataniele Piol, M.D., Rita Bianchi, M.D., Francesca Pitto, M.D., Marco Mora, M.D., Carlo Terrone, M.D., Valerio G. Vellone, M.D., Ph.D., Antonio Lopez-Beltran, M.D., Ph.D., Carlo Toncini, M.D., and Bruno Spina, M.D.
  BACKGROUND: Multiple primary tumors in the same patient are reported to occur in the range of 2–17%. Histopathological recognition of an unsuspected tumor is important as it could influence therapeutic decisions and affect patients’ prognosis, but synchronous concomitant malignancies can be a diagnostic challenge for the pathologist. CASE: We report a case of prostatic acinar adenocarcinoma metastatic to a pelvic lymph node also affected by Hodgkin disease in a 73-year-old man. After prostatic biopsies positive for prostatic adenocarcinoma, the patient underwent a radical prostatectomy with bilateral pelvic lymphadenectomy. Pathological examination confirmed the initial diagnosis, revealing a bilateral high-grade prostatic adenocarcinoma involving about 70% of the prostate with extensive extracapsular invasion. A metastasis of prostatic adenocarcinoma was found in 1 of the left pelvic lymph nodes; all pelvic lymph nodes showed an architectural effacement due to a distinct neoplastic proliferation characterized by large cells consistent with Reed-Sternberg and Hodgkin cells, confirmed by immunohistochemistry reactions.
Conclusion:
This case is, to the best of our knowl-edge, the first case of a urological neoplasm, namely a prostatic acinar adenocarcinoma, metastasizing to a lymph node simultaneously involved by Hodgkin disease.
Keywords:  adenocarcinoma, collision metastasis, Hodgkin lymphoma, lymph node, metastasis, pelvic lymph node, prostate, prostate cancer, prostatic neoplasms, prostatic adenocarcinoma
   
   
  Acrobat Reader 7.0 is recommended to properly view and print the article.
Reader can be downloaded from